SeaChange uses unique computational techniques to find new uses for known drugs that are already safe in humans. We aim to make better use of existing drugs, to reduce the likelihood of drug failure in clinical studies, and to reduce the need for toxicity testing in animals.
"By providing a way to identify the unintended targets of a drug, this advance will not only help streamline the drug development pipeline, but also will provide valuable guidance in efforts to repurpose existing drugs for new diseases and conditions."
— Peter Preusch PhD, NIH NIGMS, as reported by UCSF
"Researchers have identified thousands of new targets for existing drugs using a computer program that compares the molecular structures of drug compounds and chemicals that occur naturally in the body. The technique can be used to uncover new applications or reveal potential side effects for drugs already on the market." — Nature News
SeaChange uses new technology to predict off-target drug activities.
"It would be a tremendous opportunity if we were to find a new way forward for a compound that we previously had reason to shelve."
SeaChange provides off-targets, mechanism of action, and library prediction services.
