The Similarity Ensemble Approach (SEA) is a new method to predict drug side effects and new therapeutic opportunities. SEA technology is motivated by two ideas: that proteins can be related by their pharmacology, and that one can exploit these network relationships to discover new targets for established drugs.
New drug uses
We are expanding core SEA technology to uncover new uses for known drugs. SEA was featured among Wired magazine's top scientific breakthroughs of 2009. See Keiser & Setola et al, Nature, 2009 (» view).
Drug side effects
Adverse drug reactions are the second most common reason that drugs fail in clinical trials, after efficacy. We've a developed novel, fully-automated method to screen for side effects among drugs or preclinical compounds, on a broad scale. See Lounkine & Keiser et al, Nature, 2012 (» view).